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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically focused on practical aspects of the study design, including the recruitment process and consent as well as adherence to the use of commonly available equipment.
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Pragmatic is a software development company that offers a broad range of casino games on online gambling platforms. Pragmatic's iGaming software is used by leading operators and land based casinos. The company provides front-end design tools, analysis, promotions, marketing payment systems, security, customer support and bug reporting. The company also offers security, high-quality graphics, gameplay and security.
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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for a pragmatic trial to be valid and to reduce bias in the results, is also necessary. However, too much heterogeneity can result in problems with the design of the trial.
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Legality
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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. Usually, they are ordered by policymakers and practitioners to guide their decisions. They can be used to determine the cause-effect relationship of an intervention and its effects. They should not, however be used to replace explanatory studies.
The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis and pragmatic trials, which inform the policy and practice of. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a practical trial, including recruitment, design and delivery of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority were conducted in primary care settings.